Symptoms, Diagnosis and Treatment of a Thalamic Glioma

Thalamic glioma on an MRI scan

Children with thalamic gliomas usually develop their first symptoms when the tumor begins to compress the adjoining ventricle, resulting in a blockage of the flow of cerebrospinal fluid (CSF). This phenomenon, which most commonly causes headache and vomiting, is referred to as hydrocephalus and warrants emergency attention. (This is referred to as “mass effect,” as the growth of a tumor presses against nearby brain tissue.) Tumors also commonly interfere with normal fibers surrounding the thalamus and can manifest with gait imbalance, motor weakness or abnormal tones.

Unless a patient needs emergency treatment of hydrocephalus, the first step in investigating a suspected brain tumor is obtaining an MRI scan. The MRI provides very detailed information pertaining to the extent (unilateral or bilateral), growth character (focal or infiltrative), and potentially the tumor type and grade (from JPA through Grades II-IV). The goal is to gather as much information as possible before treatment planning begins.

If the MRI scan indicates the tumor is a focal (clearly defined) JPA of the thalamus, surgical removal of the tumor provides a realistic chance for a cure. Unfortunately, for most astrocytomas of the thalamus (infiltrative or diffuse Grade II-IV tumors), surgical removal is not an option. In those cases, surgery should be reserved purely for biopsy, to treat hydrocephalus or to reduce the mass effect.


If a biopsy is needed, an experienced neurosurgeon can usually use minimally invasive techniques, including stereotactic needle or endoscopic surgery, both of which remove small samples of a tumor through small skin and bone openings. More traditional surgery is sometimes required if a neurosurgeon is concerned about sampling error or bleeding potential.


Like most other gliomas of the brain, thalamic gliomas are generally treated using radiation therapy with or without chemotherapy. The inclusion or choice of chemotherapy is dependent on the result of tumor biopsy. The treatment usually does not require hospitalization.

At Weill Cornell Medicine Neurological Surgery, our pediatric neurosurgeons are highly skilled in the most advanced procedures for treating rare brain tumors. Our relationships with top hospitals, including NewYork/Presbyterian and Memorial Sloan-Kettering, allow our surgeons access to the very best facilities and specialists, as well as the most leading-edge research laboratories, to ensure that each child gets the very best treatment available.

Reviewed by Mark M. Souweidane, M.D.
Last reviewed/last updated: July 2015



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Weill Cornell Medicine Thalamic Glioma Registry 1300 York Ave., New York New York, NY 10022 Phone: (212) 746-2207